RAF1 Proteins, Antibodies, cDNA Clones Research Reagents

RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase) is a protein coding gene located on human chromosome 3p25.2. RAF1 is also known as NS5, CRAF, Raf-1, c-Raf, and CMD1NN. The human RAF1 gene encodes a 73052 Da protein containing 648 amino acids. The RAF1 protein is ubiquitously expressed in bone marrow, heart and other tissues. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. RAF1 is related to identical protein binding and protein kinase activity. ARAF is an important paralog of RAF1 gene. RAF1 is associated with some diseases, including Noonan Syndrome 5 and Leopard Syndrome 2.

RAF1 Protein (1)

    RAF1 Antibody (2)

      RAF1 cDNA Clone (28)

      RAF1 Lysate (1)

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        RAF1 Background

        RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

        RAF1 References

        • Zhang K, Chen H, Zhang B, et al. Overexpression of Raf-1 and ERK1/2 in sacral chordoma and association with tumor recurrence. International Journal of Clinical and Experimental Pathology. 2015;8(1):608-614.

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