PXN Antibodies, cDNA Clones Research Reagents

PXN (Paxillin) is a protein coding gene located on human chromosome 12q24.23. The human PXN gene encodes a 64505 Da protein containing 591 amino acids. The PXN protein is ubiquitously expressed in placenta, fat and other tissues. Among its related pathways are RET signaling and Signaling by GPCR. PXN is related to protein kinase binding and integrin binding. TGFB1I1 is an important paralog of PXN gene. PXN is associated with some diseases, including Neurofibromatosis, Type Ii and Papilloma.

PXN Antibody (1)

    PXN cDNA Clone (30)

    PXN qPCR Primer (1)

    PXN Background

    PXN was significantly upregulated in cervical cancer, which associated with tumor stage, poor differentiation, lymphovascular space invasion and lymphatic metastasis. Knockdown of PXN notably impaired cellular growth and colony formation by suppressing Bcl-2 and inducing marked apoptosis. Moreover, PXN led to resistance to radiation, and downregulation of PXN resensitized C33A cells to radiation.PXN was frequently upregulated and acted as an oncogene via regulating Bcl-2 in cervical cancer, which supports PXN as a potent therapeutic target.

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