PTEN Antibodies, cDNA Clones Research Reagents

PTEN (Phosphatase And Tensin Homolog) is a protein coding gene located on human chromosome 10q23.31. PTEN is also known as BZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23del and PTENbeta. The human PTEN gene encodes a 47166 Da protein containing 403 amino acids. The PTEN protein is ubiquitously expressed in fat, spleen and other tissues. Among its related pathways are RET signaling and B cell receptor signaling pathway (KEGG). PTEN is related to protein kinase binding and magnesium ion binding. TPTE2 is an important paralog of PTEN gene. PTEN is associated with some diseases, including Cowden Syndrome 1 and Macrocephaly/Autism Syndrome.

PTEN Antibody (1)

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    PTEN qPCR Primer (1)

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    PTEN Background

    PTEN gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translations start codons results in multiple transcript variants encoding different isoforms.

    PTEN References

    • Shinde SR, Maddika S. PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7. Nature Communications. 2016;7:10689.

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