PSME2 Proteins, Antibodies, cDNA Clones Research Reagents

PSME2 (Proteasome Activator Subunit 2) is a protein coding gene located on human chromosome 14q12. PSME2 is also known as PA28B, REGbeta and PA28beta. The human PSME2 gene encodes a 27402 Da protein containing 239 amino acids. The PSME2 protein is ubiquitously expressed in duodenum, small intestine and other tissues. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. PSME1 is an important paralog of PSME2 gene. PSME2 is associated with some diseases, including Ulceroglandular Tularemia and Cystic Fibrosis.

PSME2 Protein (1)

    PSME2 Antibody (3)

      PSME2 cDNA Clone (30)

      PSME2 qPCR Primer (1)

      More Product Popular With Customers

      PSME2 Background

      PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME2 gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring.

      PSME2 References

      • Ahn K. et al., 1996, J Biol Chem. 271 (30): 18237-42.
      • Rual Jean-François. et al., 2005, Nature. 437 (7062): 1173-8.
      • Ahn JY. et al., 1995, FEBS Lett. 366 (1): 37-42.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.