PRMT6 Proteins, Antibodies, cDNA Clones Research Reagents

All PRMT6 reagents are produced in house and quality controlled, including 5 PRMT6 Antibody, 34 PRMT6 Gene, 1 PRMT6 IP Kit, 1 PRMT6 Lysate, 1 PRMT6 Protein, 2 PRMT6 qPCR. All PRMT6 reagents are ready to use.

PRMT6 Protein (1)

    PRMT6 Antibody (5)

      PRMT6 cDNA Clone (34)

      In cloning vector


      In lentiviral vector

      In expression vector

      PRMT6 Lysate (1)

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        PRMT6 Background

        Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H3R2), and this negatively regulates the lysine methylation of H3K4 resulting in gene repression. PRMT6 plays a key role in coupling process by functioning as a transcriptional coactivator that can regulate alternative splicing. PRMT6 coactivates the progesterone, glucocorticoid and oestrogen receptors in luciferase reporter assays in a hormone-dependent manner. Small interfering RNA (siRNA) oligonucleotide duplex knockdown of PRMT6 disrupts oestrogen-stimulated transcription of endogenous GREB1 and progesterone receptor in MCF-7 breast cancer cells. Neutralizing the activity of PRMT6 could inhibit tumor progression and may be of cancer therapeutic significance.

        PRMT6 References

        • Hyllus D, et al., 2007, Genes Dev. 21(24): 3369-80.
        • Lakowski, TM. et al., 2008, J Biol Chem. 283 (15): 10015-25. 
        • Michaud-Levesque, J. et al., 2009, J Biol Chem. 284 (32): 21338-46.
        • Harrison, MJ. et al., 2010, Nucleic acids Res. Jan 4.

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