PRKACA Antibodies, cDNA Clones Research Reagents

PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha, also known as PKACA; PPNAD4), located on 19p13.12, is a Protein Coding gene. This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. The gene produces a 40590 Da protein composed of 351 amino acids. PRKACA has been documented as a pivotal regulator in meiosis and mitosis arrest. Diseases such as Pigmented Nodular Adrenocortical Disease, Primary, 4 are associated with PRKACA.

PRKACA Antibody (1)

    PRKACA cDNA Clone (29)

    PRKACA Background

    PRKACA encodes a catalytic subunit of protein kinase A, and almost all fibrolamellar carcinomas have a heterozygous 400-kb deletion that leads to the fusion of DNAJB1 and PRKACA. The resulting DNAJB1-PRKACA fusion transcript is believed to activate protein kinase A by dysregulation of the catalytic portion of the protein. In contrast, PRKAR1A encodes one of the regulatory subunits of protein kinase A. Protein kinase A (PRKACA) has been documented as a pivotal regulator in meiosis and mitosis arrest. Somatic mutations of the catalytic subunit of the cyclic AMP-dependent protein kinase (PRKACA) gene have been identified in about 35% of cortisol-producing adenomas (CPAs), with the affected patients showing overt Cushing's syndrome.

    PRKACA References

    • Nakajima Y, et al. (2014) Somatic mutations of the catalytic subunit of cyclic amp-dependent protein kinase (prkaca) gene in japanese patients with several adrenal adenomas secreting cortisol [rapid communication]. Endocr J 61 (8): 825-832.
    • Graham RP, et al. (2018) Fibrolamellar carcinoma in the carney complex: Prkar1a loss instead of the classic dnajb1-prkaca fusion. Hepatology 68 (4): 1441-1447.
    • Cui C, et al. (2008) Cdc25b acts as a potential target of prkaca in fertilized mouse eggs. Biol Reprod 79 (5): 991-998.

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