PKC iota Proteins, cDNA Clones Research Reagents

PRKCI (Protein Kinase C Iota) is a protein coding gene located on human chromosome 3q26.2. PRKCI is also known as PKCI, DXS1179E and nPKC-iota. The human PRKCI gene encodes a 68262 Da protein containing 596 amino acids. The PRKCI protein is ubiquitously expressed in stomach, thyroid and other tissues. Among its related pathways are Sweet Taste Signaling and Integrin Pathway. PRKCI is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. PRKCZ is an important paralog of PRKCI gene. PRKCI is associated with some diseases, including Lung Cancer and Lung Squamous Cell Carcinoma.

PKC iota Protein (1)

    PKC iota cDNA Clone (18)

    NM_002740.5

    In cloning vector

    In lentiviral vector

    In expression vector

    PKC iota Lysate (1)

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      PKC iota Background

      Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and PKC subfamily. PRKCI contains one AGC-kinase C-terminal domain, one OPR domain, one phorbol-ester/DAG-type zinc finger and one protein kinase domain. PRKCI is predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. It is highly expressed in non-small cell lung cancers. PRKCI is a calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. It may play a role in the secretory response to nutrients. PRKCI is involved in cell polarization processes and the formation of epithelial tight junctions. It is implicated in the activation of several signaling pathways including Ras, c-Src and NF-kappa-B pathways. PRKCI functions in both pro- and anti-apoptotic pathways. It functions in the RAC1/ERK signaling required for transformed growth. PRKCI plays a role in microtubule dynamics through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). PRKCI might be a target for novel lipid activators that are elevated during nutrient-stimulated insulin secretion.

      PKC iota References

      • Selbie L.A. et al.,1993, J. Biol. Chem. 268:24296-302.
      • Diaz-Meco M.T. et al.,1996, Mol. Cell. Biol. 16:105-114.
      • Noda Y. et al.,2001, Genes Cells 6:107-119.
      • White W.O.et al.,2002, J. Cell. Biochem. 85:42-53.
      • Messerschmidt A. et al., 2005, J. Mol. Biol. 352:918-931.

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