PHF11 Antibodies, cDNA Clones Research Reagents

PHF11 (PHD Finger Protein 11, also known as APY; BCAP; IGEL; IGER; IGHER; NYREN34; NY-REN-34), located on 13q14.2, is a Protein Coding gene. This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. The gene produces a 37582 Da protein composed of 331 amino acids. PHF11 is a transcriptional co-activator of the Th1 effector cytokine genes, interleukin-2 (IL2) and interferon-γ (IFNG), co-operating with nuclear factor kappa B (NF-κB). Diseases such as Asthma and Dermatitis are associated with PHF11.

PHF11 Antibody (1)

    PHF11 cDNA Clone (30)

    PHF11 qPCR Primer (1)

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    PHF11 Background

    Polymorphisms within plant homeodomain finger protein 11 (PHF11) are associated with total IgE, allergic asthma, and eczema. PHF11 is a transcriptional co-activator of the Th1 effector cytokine genes, interleukin-2 (IL2) and interferon-γ (IFNG), co-operating with nuclear factor kappa B (NF-κB). Initial studies have reported strong associations of variants in the plant homeodomain zinc finger protein 11 (PHF11) gene with serum IgE levels, asthma, airway hyper-responsiveness, and childhood atopic dermatitis. PHF11 interacted with the ssDNA-binding protein RPA and was found in a complex with several nucleases, including the 5' dsDNA exonuclease EXO1. Biochemical experiments demonstrated that PHF11 stimulates EXO1 by overcoming its inhibition by RPA, suggesting that PHF11 acts (in part) by promoting 5' end resection at RPA-bound sites of DNA damage.

    PHF11 References

    • Rahman N, et al. (2010) A role for the atopy-associated gene phf11 in t-cell activation and viability. Immunol Cell Biol 88 (8): 817-824.
    • Muscat P, et al. (2015) Phf11 expression and cellular distribution is regulated by the toll-like receptor 3 ligand polyinosinic:Polycytidylic acid in hacat keratinocytes. BMC Immunol 16 69.
    • Clarke E, et al. (2008) Functional characterization of the atopy-associated gene phf11. J Allergy Clin Immunol 121 (5): 1148-1154.e1143.

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