Periostin Proteins, Antibodies, cDNA Clones Research Reagents

POSTN (Periostin) is a protein coding gene located on human chromosome 13q13.3. POSTN is also known as PN, OSF2, OSF-2 and PDLPOSTN. The human POSTN gene encodes a 93314 Da protein containing 836 amino acids. The POSTN protein is broadly expressed in skin, urinary bladder and other tissues. Among its related pathways are Amplification and Expansion of Oncogenic Pathways as Metastatic Traits and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease. POSTN is related to heparin binding and cell adhesion molecule binding. TGFBI is an important paralog of POSTN gene. POSTN is associated with some diseases, including Melorheostosis and Myocardial Infarction.

Periostin Protein (2)

    Periostin Antibody (6)

      Periostin cDNA Clone (26)


      Periostin Lysate (2)

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        Periostin Background

        Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Although the detailed function of Postn is still unclear, Postn-integrin interaction is thought to be involved in tumor development. Postn is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis, and can be a useful marker to predict the behavior of cancer.

        Periostin References

        • Kudo,Y. et al., 2007, Histol Histopathol. 22 (10):1167-1174.
        • Li, J.S. et al., 2007, World J Gastroenterol. 13 (39): 5261-5266.
        • Oku, E. et al., 2008, Int J Hematol. 88 (1): 57-63.
        • Hamilton, D.W. et al., 2008, J Cell Commun Signal. 2(1-2):9-17.
        • Puglisi, F.J et al., 2008, Clin Pathol. 61 (4): 494-498.
        • Conway, S. J. et al., 2008, Curr Genomics. 9 (8): 548-555.

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