Pentraxin 3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Pentraxin 3 reagents are produced in house and quality controlled, including 6 Pentraxin 3 Antibody, 1 Pentraxin 3 ELISA, 13 Pentraxin 3 Gene, 1 Pentraxin 3 Lysate, 1 Pentraxin 3 Protein, 1 Pentraxin 3 qPCR. All Pentraxin 3 reagents are ready to use.

Pentraxin 3 Protein (1)

    Pentraxin 3 Antibody (6)

      Pentraxin 3 ELISA Kit & Match Antibody ELISA Pair Set (1)

      Pentraxin 3 cDNA Clone (13)

      NM_002852

      Pentraxin 3 qPCR Primer (1)

      Pentraxin 3 Lysate (1)

        Pentraxin 3 Background

        Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains onepentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.

        Pentraxin 3 References

        • Rolph,M.S. et al., 2002, Arterioscler Thromb Vasc Biol. 22 (5):e10-4.
        • Mantovani A., et al., 2003, Vaccine. 21:S43-S47.
        • Luchetti,M.M. et al., 2004, Clin Exp Rheumatol. 22 (3):S66-72.
        • Mantovani, A. et al., 2006, Vascul Pharmacol. 45 (5):326-30.
        • Inforzato A., et al., 2008, J. Biol. Chem. 283:10147-61.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.