PDGFRB Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PDGFRB (Platelet Derived Growth Factor Receptor Beta) is a protein coding gene located on human chromosome 5q32. PDGFRB is also known as IMF1, KOGS, IBGC4, JTK12, PDGFR, PENTT, CD140B, PDGFR1 and PDGFR-1. The human PDGFRB gene encodes a 123968 Da protein containing 1106 amino acids. The PDGFRB protein is broadly expressed in gall bladder, placenta and other tissues. Among its related pathways are RET signaling and Phospholipase D signaling pathway. PDGFRB is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. PDGFRA is an important paralog of PDGFRB gene. PDGFRB is associated with some diseases, including Premature Aging Syndrome, Penttinen Type and Kosaki Overgrowth Syndrome.

PDGFRB Protein (10)

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      PDGFRB ELISA Kit & Match Antibody ELISA Pair Set (1)

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      PDGFRB Lysate (9)

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        PDGFRB Background

        The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.

        PDGFRB References

        • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
        • Suzuki S, et al. (2010) Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor- phosphorylation, and microvessel density in gastric cancer. BMC cancer. 10: 659.

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