PD-L2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PDCD1LG2 (Programmed Cell Death 1 Ligand 2) is a protein coding gene located on human chromosome 9p24.1. PDCD1LG2 is also known as B7DC, Btdc, PDL2, CD273, PD-L2, PDCD1L2 and bA574F11.2. The human PDCD1LG2 gene encodes a 30957 Da protein containing 273 amino acids. The PDCD1LG2 protein is broadly expressed in spleen, lymph node and other tissues. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. CD274 is an important paralog of PDCD1LG2 gene. PDCD1LG2 is associated with some diseases, including Cysticercosis and Testicular Lymphoma.

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        PD-L2 Background

        Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

        PD-L2 References

        • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
        • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
        • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.

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