PD-1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PDCD1 (Programmed Cell Death 1) is a protein coding gene located on human chromosome 2q37.3. PDCD1 is also known as PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l and hSLE1. The human PDCD1 gene encodes a 31647 Da protein containing 288 amino acids. The PDCD1 protein is biasedly expressed in lymph node, spleen and other tissues. Among its related pathways are T cell receptor signaling pathway and Innate Immune System. PDCD1 is related to obsolete signal transducer activity. PDCD1 is associated with some diseases, including Systemic Lupus Erythematosus 2 and Multiple Sclerosis.

PD-1 Protein (22)

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    PD-1 ELISA Kit & Match Antibody ELISA Pair Set (2)

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    PD-1 Lysate (18)

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      PD-1 Background

      Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

      PD-1 References

      • James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
      • Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
      • del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
      • Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.

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