PCBP1 Proteins, cDNA Clones Research Reagents

PCBP1 (Poly(RC) Binding Protein 1) is a protein coding gene located on human chromosome 2p13.3. PCBP1 is also known as HNRPX, HNRPE1, hnRNP-X, HEL-S-85, and hnRNP-E1. The human PCBP1 gene encodes a 37498 Da protein containing 356 amino acids. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. PCBP1 is related to nucleic acid binding and RNA binding. PCBP2 is an important paralog of PCBP1 gene. PCBP1 is associated with some diseases, including Deafness, Autosomal Recessive 17 and Tremor, Hereditary Essential, 4.

PCBP1 Protein (1)

    PCBP1 cDNA Clone (29)

    PCBP1 qPCR Primer (1)

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    PCBP1 Background

    Poly(rC)-binding protein 1, also known as Heterogeneous nuclear ribonucleoprotein E1, Alpha-CP1, Nucleic acid-binding protein SUB2.3 and PCBP1, is a family member of heterogeneous nuclear ribonucleoproteins (hnRNPs) that belong to RNA-binding proteins and bear three KH domains. PCBP1 is loosely bound in the nucleus. It may shuttle between the nucleus and the cytoplasm. It is abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. PCBP1 is widely expressed in many human tissues and involved in the regulation of transcription, transportation process, and function of RNA molecules. PCBP1 plays a pivotal role in post-transcriptional regulation for RNA metabolism and RNA function in gene expression. PCBP1 acts as a negative regulator of CD44 variants splicing in HepG2 cells, and loss of PCBP1 in human hepatic tumor contributes to the formation of a metastatic phenotype.

    PCBP1 References

    • Evans,J.R. et al., 2003, Oncogene  22 (39): 8012-20.
    • Huo,L.R. et al., 2008, Biochim Biophys Acta  1784 (11):1524-33.
    • Huo,L.R. et al., 2009, Beijing Da Xue Xue Bao  41 (4):402-8.
    • Zhang,T. et al., 2010, Mol Cancer 9 :72.

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