P38 Gamma/MAPK12 Proteins, Antibodies, cDNA Clones Research Reagents

MAPK12 (Mitogen-Activated Protein Kinase 12, also known as ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA), located on 22q13.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 41940 Da protein composed of 367 amino acids. Activation of members of the mitogen-activated protein kinase family is a major mechanism for the transduction of extracellular signals. Diseases such as Breast Cancer are associated with MAPK12. The related pathways of MAPK12 include ATM Pathway and Organelle biogenesis and maintenance.

P38 Gamma/MAPK12 Protein (2)

    P38 Gamma/MAPK12 Antibody (1)

      P38 Gamma/MAPK12 cDNA Clone (1)


      In expression vector

      P38 Gamma/MAPK12 Lysate (2)

        P38 Gamma/MAPK12 Background

        ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase that acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 2 to 3 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability, and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

        P38 Gamma/MAPK12 References

        • Stiffler MA. et al., 2006, J Am Chem Soc. 128 (17): 5913-22.
        • Joneson T. et al., 1997, J Mol Med. 75 (8): 587-93.
        • Hou SW. et al., 2010, Cancer Res. 70 (7): 2901-10.

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