OMGP Proteins, Antibodies, cDNA Clones Research Reagents

OMG (Oligodendrocyte Myelin Glycoprotein, also known as OMGP), located on 17q11.2, is a Protein Coding gene. The gene produces a 49608 Da protein composed of 440 amino acids. OMG is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). It may also be involved in the formation and maintenance of myelin sheaths. Diseases such as Prolapse Of Urethra and Neurofibromatosis, Type I are associated with OMG. The related pathways of OMG include Signaling by GPCR and p75 NTR receptor-mediated signaling.

OMGP Protein (3)

    OMGP Antibody (3)

      OMGP cDNA Clone (39)

      NM_002544.3
      NM_001260823.1
      XM_002718940.1

      OMGP Lysate (3)

        OMGP Background

        Oligodendrocyte-myelin glycoprotein, also known as OMG and OMGP, is a cell membrane protein that contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participates in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR, the receptor for Nogo. This function requires its leucine-rich repeat domain, a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation, neuronal sprouting, and myelination are crucial processes involved in brain development and regeneration after injury.

        OMGP References

        • Viskochil D., et al.,(1991), The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol. Cell. Biol. 11:906-912.
        • Mikol D.D., et al., (1990), The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate.J. Cell Biol. 110:471-479.
        • Mikol D.D., et al.,(1990), Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein.J. Cell Biol. 111:2673-2679.

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