Olig2 Antibodies, cDNA Clones Research Reagents

OLIG2 (Oligodendrocyte Transcription Factor 2, also known as BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19), located on 21q22.11, is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog. The gene produces a 32385 Da protein composed of 323 amino acids. This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Diseases such as Oligodendroglioma and T-Cell Acute Lymphoblastic Leukemia are associated with OLIG2. The related pathways of OLIG2 include Neural Crest Differentiation and Neural Stem Cells and Lineage-specific Markers.

Olig2 Antibody (4)

    Olig2 cDNA Clone (1)

    NM_005806.3

    In expression vector

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    Olig2 Background

    Olig2, also known as Oligo2, is a basic helix-loop-helix transcription factor that is expressed in oligodendroglial tumors of the brain. Oligo2 is structurally similar to OLIG1. Both of them have non-overlapping developmental functions in patterning, neuron subtype specification, and the formation of oligodendrocytes. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Its over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in down syndrome. Olig2 may be a cause of a form of T-cell acute lymphoblastic leukemia.

    Olig2 References

    • Wang J, et al., 2000, Proc Natl Acad Sci. 97(7): 3497-502.
    • Lu QR, et al., 2001, Proc Natl Acad Sci. 98(19): 10851-6.
    • Marie Y, et al., 2001, Lancet. 358(9278): 298-300.

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