NKp30/NCR3 Proteins, Antibodies, cDNA Clones Research Reagents

NCR3 (Natural Cytotoxicity Triggering Receptor 3, also known as 1C7; MALS; CD337; LY117; NKp30), located on 6p21.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, and rat. The gene produces a 21593 Da protein composed of 201 amino acids. The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. Diseases such as Malaria, Mild, and Malaria are associated with NCR3. The related pathways of NCR3 include the Immune response Role of DAP12 receptors in NK cells and Hematopoietic Stem Cells and Lineage-specific Markers.

NKp30/NCR3 Protein (5)

NKp30/NCR3 Antibody (4)

    NKp30/NCR3 cDNA Clone (4)

    NM_147130.1

    In expression vector

    In lentiviral vector

    AJ430418.1

    In cloning vector

    AJ278389.1

    In cloning vector

    NKp30/NCR3 qPCR Primer (1)

    NKp30/NCR3 Lysate (5)

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      NKp30/NCR3 Background

      Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp30, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive, but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.

      NKp30/NCR3 References

      • Warren HS, et al. (2005) Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan. J Immunol. 175(1): 207-12.
      • Mulcahy H, et al. (2006) LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. Immunogenetics. 57(12): 893-903.
      • Hsieh CL, et al. (2006) NKp30 is a functional activation receptor on a subset of rat natural killer cells. Eur J Immunol. 36(8): 2170-80.
      • Ponnampalam AP, et al. (2008) Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium. Eur J Immunol. 38(1): 216-26.

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