Neuropilin-2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Neuropilin-2 reagents are produced in house and quality controlled, including 5 Neuropilin-2 Antibody, 2 Neuropilin-2 ELISA, 14 Neuropilin-2 Gene, 3 Neuropilin-2 Lysate, 3 Neuropilin-2 Protein. All Neuropilin-2 reagents are ready to use.

Neuropilin-2 Protein (3)

    Neuropilin-2 Antibody (5)

      Neuropilin-2 ELISA Kit & Match Antibody ELISA Pair Set (2)

      Neuropilin-2 cDNA Clone (14)

      NM_201266.2

      In expression vector

      NM_001077404.1

      Neuropilin-2 Lysate (3)

        Neuropilin-2 Background

        Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.

        Neuropilin-2 References

        • Chen H. et al., 1997, Neuron. 19: 547-59.
        • Bielenberg DR. et al., 2006, Exp Cell Res. 312: 584-93.
        • Yuan L. et al., 2002, Development. 129: 4797-806.
        • Benoit F. et al., 2006, Blood. 108: 1243-50.
        • Sabrina C. et al., 2007, J Biol Chem. 282: 30346-56.
        • Gray MJ. et al., 2008, J Natl Cancer Inst. 100: 109-20.

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