Neuregulin-1 Proteins, Antibodies, cDNA Clones Research Reagents

All Neuregulin-1 reagents are produced in house and quality controlled, including 3 Neuregulin-1 Antibody, 41 Neuregulin-1 Gene, 13 Neuregulin-1 Lysate, 14 Neuregulin-1 Protein, 1 Neuregulin-1 qPCR. All Neuregulin-1 reagents are ready to use.

Neuregulin-1 Protein (14)

    Neuregulin-1 Antibody (3)

      Neuregulin-1 cDNA Clone (41)

      NM_013956.3
      NM_013957.3

      Neuregulin-1 qPCR Primer (1)

      Neuregulin-1 Lysate (13)

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        Neuregulin-1 Background

        Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

        Neuregulin-1 References

        • Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
        • Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
        • Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.

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