MSRB3 Proteins, cDNA Clones Research Reagents

MSRB3 (Methionine Sulfoxide Reductase B3, also known as DFNB74), located on 12q14.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and A.thaliana. The gene produces a 20702 Da protein composed of 192 amino acids. The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. Diseases such as Deafness, Autosomal Recessive 74, and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb are associated with MSRB3. The related pathways of MSRB3 include Protein repair and Metabolism of proteins.

MSRB3 Protein (3)

    MSRB3 cDNA Clone (15)

    MSRB3 qPCR Primer (1)

    MSRB3 Lysate (2)

      MSRB3 Background

      MSRB3 (Methionine Sulfoxide Reductase B3) is a Protein Coding gene. The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. This cysteine residue of MSRB3 is conserved in orthologs from yeast to humans and is involved in binding structural zinc. The affected individuals of six unrelated families were homozygous for the same transversion (c.265T>G) in MSRB3. In the inner ear, it is found in the sensory epithelium of the organ of Corti and vestibular end organs as well as in cells of the spiral ganglion. MSRB3-catalyzed reduction of methionine sulfoxides to methionine is essential for hearing. Diseases associated with MSRB3 include Deafness, Autosomal Recessive 74, and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb.

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