MMP19 Proteins, Antibodies, cDNA Clones Research Reagents

MMP19 (Matrix Metallopeptidase 19, also known as CODA; MMP18; RASI-1), located on 12q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. The gene produces a 57357 Da protein composed of 508 amino acids. This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Diseases such as Cavitary Optic Disc Anomalies and Multiple Sclerosis are associated with MMP19.

MMP19 Protein (1)

    MMP19 Antibody (1)

      MMP19 cDNA Clone (1)

      NM_001272101.1

      In expression vector

      MMP19 Background

      MMP19, also known as RASI-1, is a member of the peptidase M1A family. It contains 4 hemopexin-like domains and is expressed in the mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart, and blood vessel walls. It is a matrix metalloproteinase (MMP). Proteins of the MMP family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP19 may play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 is frequent in RA patients.

      MMP19 References

      • Cossins J., et al.,(1996), Identification of MMP-18, a putative novel human matrix metalloproteinase. Biochem. Biophys. Res. Commun. 228:494-498.
      • Pendas A.M., et al., (1997), Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution.J. Biol. Chem. 272:4281-4286.
      • Kolb C., et al.,(1997), The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient.Immunol. Lett. 57:83-88.

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