MKK6 Proteins, Antibodies, cDNA Clones Research Reagents

MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6, also known as MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3), located on 17q24.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog. The gene produces a 37492 Da protein composed of 334 amino acids. This gene encodes a member of the dual-specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. Diseases such as Cardiomyopathy, Familial Hypertrophic, 25, and Ischemia are associated with MAP2K6. The related pathways of MAP2K6 include Regulation of TP53 Activity through Acetylation and Nucleotide-binding domain, leucine-rich repeat-containing receptor (NLR) signaling pathways.

MKK6 Protein (4)

    MKK6 Antibody (3)

      MKK6 cDNA Clone (15)

      MKK6 qPCR Primer (1)

      MKK6 Lysate (4)

        MKK6 Background

        Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors, cytokines, ultraviolet light, and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle, heart, and to a lesser extent in liver or pancreas.

        MKK6 References

        • Raingeaud J., et al.,(1996), MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16:1247-1255.
        • Stein B., et al., (1996), Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade.J. Biol. Chem. 271:11427-11433.
        • Han J., et al.,(1996), Characterization of the structure and function of a novel MAP kinase kinase (MKK6).J. Biol. Chem. 271:2886-2891.

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