MKK4 Proteins, Antibodies, cDNA Clones Research Reagents

MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4, also known as JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1), located on 17p12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, and frog. The gene produces a 44288 Da protein composed of 399 amino acids. This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Diseases such as Ovarian Serous Carcinoma and Cardiomyopathy, Familial Hypertrophic, 25 are associated with MAP2K4. The related pathways of MAP2K4 include Association Between Physico-Chemical Features and Toxicity Associated Pathways and Apoptosis Modulation and Signaling.

MKK4 Protein (1)

    MKK4 Antibody (1)

      MKK4 cDNA Clone (16)


      In expression vector

      MKK4 qPCR Primer (1)

      MKK4 Lysate (1)

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        MKK4 Background

        Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / JNKK1 has been shown to activate MAPK8 / JNK1, MAPK9 / JNK2, and MAPK14 / p38, but not MAPK1 / ERK2 or MAPK3 / ERK1. MAP2K4 / JNKK1 is phosphorylated, and thus activated by MAP3K1 / MEKK. The stress-activated protein kinase (SAPK) pathways represent phosphorylation cascades that convey pro-apoptotic signals. The mitogen-activated protein kinase kinase (MAPKK) homolog MAP2K4 ( MKK4, SEK, JNKK1 ) is a centrally-placed mediator of the SAPK pathways.

        MKK4 References

        • Lin A, et al.,1995, Science 268 (5208): 286-90.
        • Su,G.H. et al., 2002, Hum Mutat. 19 (1):81.
        • Lee, et al., 2002, Proc. Natl. Acad. Sci. USA. 99 (22): 14189-94.
        • Bouzakri,K. et al., 2007, J Biol Chem. 282 (11):7783-9.

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