MKK4 Proteins, Antibodies, cDNA Clones Research Reagents

MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4, also known as JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1), located on 17p12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, and frog. The gene produces a 44288 Da protein composed of 399 amino acids. This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Diseases such as Ovarian Serous Carcinoma and Cardiomyopathy, Familial Hypertrophic, 25 are associated with MAP2K4. The related pathways of MAP2K4 include Association Between Physico-Chemical Features and Toxicity Associated Pathways and Apoptosis Modulation and Signaling.

MKK4 Protein (1)

    MKK4 Antibody (1)

      MKK4 cDNA Clone (16)

      NM_003010.3

      In expression vector

      MKK4 qPCR Primer (1)

      MKK4 Lysate (1)

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        MKK4 Background

        Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / JNKK1 has been shown to activate MAPK8 / JNK1, MAPK9 / JNK2, and MAPK14 / p38, but not MAPK1 / ERK2 or MAPK3 / ERK1. MAP2K4 / JNKK1 is phosphorylated, and thus activated by MAP3K1 / MEKK. The stress-activated protein kinase (SAPK) pathways represent phosphorylation cascades that convey pro-apoptotic signals. The mitogen-activated protein kinase kinase (MAPKK) homolog MAP2K4 ( MKK4, SEK, JNKK1 ) is a centrally-placed mediator of the SAPK pathways.

        MKK4 References

        • Lin A, et al.,1995, Science 268 (5208): 286-90.
        • Su,G.H. et al., 2002, Hum Mutat. 19 (1):81.
        • Lee, et al., 2002, Proc. Natl. Acad. Sci. USA. 99 (22): 14189-94.
        • Bouzakri,K. et al., 2007, J Biol Chem. 282 (11):7783-9.

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