Midkine Proteins, Antibodies, cDNA Clones Research Reagents

MDK (Midkine, also known as MK; ARAP; NEGF2), located on 11p11.2, is conserved in Rhesus monkey, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 15585 Da protein composed of 143 amino acids. This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. Diseases such as Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 and Breast Adenocarcinoma are associated with MDK. The related pathways of MDK include Signaling by GPCR and NF-KappaB Family Pathway.

Midkine Protein (1)

    Midkine Antibody (1)

      Midkine cDNA Clone (26)

      NM_001012333.1
      NM_001012336.2

      Midkine qPCR Primer (1)

      Midkine Lysate (1)

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        Midkine Background

        Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis. Midkine binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase and the induction of cell proliferation. Midkine is involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. Midkine exhibited increased expression in the breast carcinomas but showed much lower expression in the normal breast tissue. Thus, it can be used as a breast carcinomas marker.

        Midkine References

        • Kadomatsu K, et al. (2004) Midkine and pleiotrophin in neural development and cancer. Cancer Lett. 204(2): 127-43.
        • Muramatsu H, et al. (1993) Midkine, a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution. Dev Biol. 159(2): 392-402.
        • Muramatsu T. (2002) Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J Biochem. 132(3): 359-71.
        • Kadomatsu K, et al. (2004) Midkine and pleiotrophin in neural development and cancer. Cancer Lett. 204(2): 127-43.

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