MICB Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents
All MICB Reagents
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MICB Protein (2)Recombinant MICB proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc & His.
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MICB Antibody (9)MICB antibodies are validated with different applications, which are WB, ELISA, IHC-P, FCM, ELISA(Cap).
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MICB ELISA Kit (2)MICB ELISA Kits are quality controlled by 8 internation QC standards which guarantee every ELISA Kit with high quality.
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MICB Lysate (2)MICB overexpression lysate was created in HEK293 Cells and intented for use as a Western blot (WB) positive control. Purification of MICB protein from the overexpression lysate was verified.
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MICB cDNA Clone (13)MICB cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each MICB of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
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MICB qPCR Primer (1)Verified forward and reverse primers for analyzing the quantitative expression of gene. The primer mix has been verified to generate satisfactory qPCR data on Roche LightCycler480.
MICB General Information
MICB Protein (2)
MICB Antibody (9)
MICB ELISA Kit & Match Antibody ELISA Pair Set (2)
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Assay Range: 78.12-5000
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Sensitivity: 16.6 pg/mLAssay Range: 62.5-4000
MICB cDNA Clone (13)
In cloning vector
In expression vector
In lentiviral vector
MICB qPCR Primer (1)
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Human MICB qPCR Primer Pair HP100035
MICB Lysate (2)
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MICB Background
MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.
MICB References
- Bauer, S. et al., 1999, Science. 285:727-729.
- Braud, V.M. et al., 1999, Curr. Opin. Immunol. 11: 100-108.
- Groh, V. et al., 2001, Nature Immunol. 2: 255-260.
- Stephens, H., 2001, Trends Immunol. 22: 378-385.
- Borrego, F. et al., 2002, Mol. Immunol. 38: 637–660.
- Groh, V. et al., 2002, Nature. 419:734-738.
Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.
