MICB Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

MICB (MHC Class I Polypeptide-Related Sequence B, also known as PERB11.2), located on 6p21.33, is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat. The gene produces a 42646 Da protein composed of 383 amino acids. This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Diseases such as Dengue Shock Syndrome and Rheumatoid Arthritis are associated with MICB. The related pathways of MICB include the Immune response Role of DAP12 receptors in NK cells and the Innate Immune System.

MICB Protein (2)

    MICB Antibody (9)

      MICB ELISA Kit & Match Antibody ELISA Pair Set (2)

      MICB cDNA Clone (13)

      NM_005931.2

      MICB qPCR Primer (1)

      MICB Lysate (2)

        MICB Background

        MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without the capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B is minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.

        MICB References

        • Bauer, S. et al., 1999, Science. 285:727-729.
        • Braud, V.M. et al., 1999, Curr. Opin. Immunol. 11: 100-108.
        • Groh, V. et al., 2001, Nature Immunol. 2: 255-260.
        • Stephens, H., 2001, Trends Immunol. 22: 378-385.
        • Borrego, F. et al., 2002, Mol. Immunol. 38: 637–660.
        • Groh, V. et al., 2002, Nature. 419:734-738.

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