MEK5/MAP2K5 Antibodies, cDNA Clones Research Reagents

MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5, also known as MEK5; MAPKK5; PRKMK5; HsT17454), located on 15q23, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 50112 Da protein composed of 448 amino acids. The protein encoded by this gene is a dual-specificity protein kinase that belongs to the MAP kinase kinase family. Diseases such as Caroli Disease and Restless Legs Syndrome are associated with MAP2K5. The related pathways of MAP2K5 include Nur77 Signaling in T-Cell and Signaling by GPCR.

MEK5/MAP2K5 Antibody (1)

    MEK5/MAP2K5 cDNA Clone (17)

    NM_145160.2

    In cloning vector

    In lentiviral vector

    MEK5/MAP2K5 Background

    MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5, also known as MEK5) is a Protein Coding gene. The protein encoded by this gene is a dual-specificity protein kinase that belongs to the MAP kinase kinase family. The signal cascade mediated by this kinase is involved in growth factor-stimulated cell proliferation and muscle cell differentiation. 4 alternatively spliced human isoforms have been reported. Diseases associated with MAP2K5 include Caroli Disease and Restless Legs Syndrome. SNP rs1026732 in MAP2K5/SKOR1 was significantly associated with restless legs syndrome (RLS). RLS is considered a genetic disease and, following a genome-wide association study conducted in 2007, the MAP2K5 gene has been regarded as the promising candidate gene for RLS.

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