MEK2 Proteins, Antibodies, cDNA Clones Research Reagents

MAP2K2 (Mitogen-Activated Protein Kinase Kinase 2, also known as CFC4; MEK2; MKK2; MAPKK2; PRKMK2), located on 19p13.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, etc. The gene produces a 44424 Da protein composed of 400 amino acids. The protein encoded by this gene is a dual-specificity protein kinase that belongs to the MAP kinase kinase family. MAP2K2 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. It also activates the ERK1 and ERK2 MAP kinases.

MEK2 Protein (1)

    MEK2 Antibody (3)

      MEK2 cDNA Clone (30)

      MEK2 Lysate (1)

        MEK2 Background

        Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion and growth factor signaling. MAP2K1 / MEK1 is a crucial modulator of Mek and Erk signaling and have potential implications for the role of MEK1 and MEK2 in tumorigenesis. MAP2K2 / MEK2 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. It also activates the ERK1 and ERK2 MAP kinases. Defects in MAP2K2 are a cause of Cardiofaciocutaneous Syndrome (CFC Syndrome) which is characterized by a distinctive facial appearance, heart defects, and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects, and hypertrophic cardiomyopathy.

        MEK2 References

        • MacDonald,T.J. et al., 2001, Nat Genet. 29 (2):143-52.
        • Mittal R., et al., 2006, Proc. Natl. Acad. Sci. USA. 103:18574-9.
        • Narumi,Y. et al., 2007, Am J Med Genet A. 143A (8):799-807.
        • Daub H., et al., 2008, Mol. Cell 31:438-448.
        • Catalanotti,F. et al., 2009, Nat Struct Mol Biol. 16 (3):294-303.

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