Mannan Binding Lectin/MBL2 Proteins, Antibodies, cDNA Clones Research Reagents

MBL2 (Mannose Binding Lectin 2, also known as MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC), located on 10q21.1, is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 26144 Da protein composed of 248 amino acids. This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. Diseases such as Mannose-Binding Lectin Deficiency and Cystic Fibrosis are associated with MBL2. The related pathways of MBL2 include Immune response Lectin induced complement pathway and Innate Immune System.

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Mannan Binding Lectin/MBL2 Protein (3)

    Mannan Binding Lectin/MBL2 Antibody (2)

      Mannan Binding Lectin/MBL2 cDNA Clone (39)


      Mannan Binding Lectin/MBL2 Lysate (3)

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        Mannan Binding Lectin/MBL2 Background

        MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defense. They bind sugar structures or acetylated compounds present on microorganisms and dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in the development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in the promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and the oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcomes for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.

        Mannan Binding Lectin/MBL2 References

        • Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94.
        • Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44.
        • Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6.
        • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
        • Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.

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