MAP1LC3A Proteins, Antibodies, cDNA Clones Research Reagents

MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 Alpha, also known as LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3), located on 20q11.22, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog. The gene produces a 14272 Da protein composed of 121 amino acids. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. Diseases such as Alzheimer's Disease 13 are associated with MAP1LC3A. The related pathways of MAP1LC3A include Nanoparticle triggered autophagic cell death and Autophagy Pathway.

MAP1LC3A Protein (1)

    MAP1LC3A Antibody (1)

      MAP1LC3A cDNA Clone (29)

      MAP1LC3A qPCR Primer (1)

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      MAP1LC3A Background

      LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. As a light chain subunit, MAP1LC3A has an important part in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP1LC3A is expressed as two alternatively spliced isoforms that are expressed in testis, brain, heart, liver, and skeletal muscle but are absent in thymus and peripheral blood leukocytes.

      MAP1LC3A References

      • He H., et al.,(2003), Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J. Biol. Chem. 278:29278-29287.
      • Deloukas P., et al., (2001), The DNA sequence and comparative analysis of human chromosome 20.Nature 414:865-871.
      • Bechtel S., et al.,(2007), The full-ORF clone resource of the German cDNA consortium.BMC Genomics 8:399-399.

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