LIFR Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LIFR (LIF Receptor Subunit Alpha, also known as SWS; SJS2; STWS; CD118; LIF-R), located on 5p13.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 123743 Da protein composed of 1097 amino acids. This gene encodes a protein that belongs to the type I cytokine receptor family. Diseases such as Stuve-Wiedemann Syndrome and Hemophagocytic Lymphohistiocytosis, Familial, 2 are associated with LIFR. The related pathways of LIFR include G-protein signaling Ras family GTPases in kinase cascades (scheme) and Activation of cAMP-Dependent PKA.

LIFR Protein (5)

    LIFR Antibody (11)

      LIFR ELISA Kit & Match Antibody ELISA Pair Set (2)

      LIFR cDNA Clone (52)

      NM_001127671.1
      NM_013584.2
      NM_031048.1
      XM_001082842.2

      LIFR Lysate (4)

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        LIFR Background

        LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.

        LIFR References

        • Gearing, D.P. et al.,1991, EMBO J. 10 (10): 2839-2848.
        • Gearing, D.P. et al.,1992, New Biol. 4 (1): 61-65.
        • Mosley, B. et al.,1996, J. Biol. Chem. 271 (51): 32635-32643.
        • Timmermann, A. et al.,2002, Eur. J. Biochem. 269 (11): 2716-2726.
        • Lass, A. et al.,2002, Fertil. Steril. 76 (6): 1091-1096.

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