Lefty2 Proteins, cDNA Clones Research Reagents

LEFTY2 (Left-Right Determination Factor 2, also known as EBAF; LEFTA; TGFB4; LEFTYA), located on 1q42.12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 40920 Da protein composed of 366 amino acids. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Diseases such as Visceral Heterotaxy and Complete Atrioventricular Canal are associated with LEFTY2. The related pathways of LEFTY2 include Signaling by NODAL and NF-KappaB Family Pathway.

Lefty2 Protein (1)

    Lefty2 cDNA Clone (14)


    In expression vector


    Lefty2 qPCR Primer (2)

    Lefty2 Lysate (1)

      Lefty2 Background

      left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determination, factor A transforming growth factor-beta superfamily), and transforming growth factor beta-4, is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. Lefty2/Lefty A may also play a role in endometrial bleeding. Mutations in Lefty2/Lefty A have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. Depletion of both Lefty1 and Lefty2 causes unchecked Nodal signaling, expansion of mesendoderm, and loss of ectoderm. The expansion of mesendoderm correlates with an extended period of rapid cellular internalization and a failure of deep-cell epiboly. The gastrulation defects of embryos depleted of Lefty1 and Lefty2 result from the deregulation of Squint signaling.

      Lefty2 References

      • Feldman B, et al. (2002) Lefty antagonism of Squint is essential for normal gastrulation. Curr Biol. 12(24): 2129-35.
      • Meno C, et al. (1999) Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol Cell. 4(3): 287-98.
      • Meno C, et al. (2001) Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev Cell. 1(1): 127-38.

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