Lamin B1/LMNB1 Antibodies, cDNA Clones Research Reagents

LMNB1 (Lamin B1) is a protein coding gene located on human chromosome 5q23.2. LMNB1 is also known as LMN, ADLD, LMN2 and LMNB. The human LMNB1 gene encodes a 66408 Da protein containing 586 amino acids. The LMNB1 protein is broadly expressed in lymph node, appendix and other tissues. Among its related pathways are Neurodegenerative Diseases and Mitotic Prophase. LMNB1 is related to structural molecule activity and phospholipase binding. LMNB2 is an important paralog of LMNB1 gene. LMNB1 is associated with some diseases, including Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant and Leukodystrophy.

Lamin B1/LMNB1 Antibody (1)

    Lamin B1/LMNB1 cDNA Clone (30)

    Lamin B1/LMNB1 Background

    Duplication of the LMNB1 gene encoding lamin B1 causes adult-onset autosomal-dominant leukodystrophy (ADLD) starting with autonomic symptoms, which are followed by pyramidal signs and ataxia. LMNB1 functions in nuclear envelope lamina and possesses a transcriptional coregulatory activity having an important role in DNA replication, cellular aging, and stress responses. Clinically, the expression level of lamin B1 is correlated positively with tumor stages, tumor sizes, and the number of nodules.

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