KLK4 Proteins, Antibodies, cDNA Clones Research Reagents

KLK4 (Kallikrein Related Peptidase 4, also known as ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein), located on 19q13.41, is conserved in chimpanzee, dog, cow, mouse, and rat. The gene produces a 27032 Da protein composed of 254 amino acids. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Diseases such as Amelogenesis Imperfecta, Hypomaturation Type, Iia1, and Amelogenesis Imperfecta Hypomaturation Type are associated with KLK4. The related pathways of KLK4 include Collagen chain trimerization and MSP-RON Signaling.

KLK4 Protein (1)

    KLK4 Antibody (5)

      KLK4 cDNA Clone (15)


      In expression vector

      In lentiviral vector


      KLK4 Lysate (1)

        KLK4 Background

        Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transition- and maturation-stage ameloblasts. KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion. Two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-2). The late protease is kallikrein 4 (KLK4). The principal functions of MMP-2 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins. Defects in Kallikrein-4 / KLK4 are the cause of Amelogenesis Imperfecta Hypomaturation type 2A1 (AI2A1) which is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions.

        KLK4 References

        • Nelson P.S., et al.,(1999), Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. Proc. Natl. Acad. Sci. U.S.A. 96:3114-3119.
        • Yousef G.M., et al., (1999), Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated.Cancer Res. 59:4252-4256.
        • Stephenson S.A., et al.,(1999), Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4.J. Biol. Chem. 274:23210-23214.

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