KIR2DL4 Proteins, Antibodies, cDNA Clones Research Reagents

All KIR2DL4 reagents are produced in house and quality controlled, including 2 KIR2DL4 Antibody, 2 KIR2DL4 Gene, 2 KIR2DL4 Lysate, 2 KIR2DL4 Protein, 1 KIR2DL4 qPCR. All KIR2DL4 reagents are ready to use.

KIR2DL4 Protein (2)

    KIR2DL4 Antibody (2)

      KIR2DL4 cDNA Clone (2)


      In expression vector

      In lentiviral vector

      KIR2DL4 qPCR Primer (1)

      KIR2DL4 Lysate (2)

        KIR2DL4 Background

        KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.

        KIR2DL4 References

        • Selvakumar A. et al., 1997, Tissue Antigens. 48 (4 Pt 1): 285-94.
        • Selvakumar A. et al., 1997, Immunol Rev. 155: 183-96.
        • Selvakumar A. et al., 1997, Tissue Antigens. 49 (6): 564-73.

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