JSRP1 Antibodies, cDNA Clones Research Reagents

JSRP1 (Junctional Sarcoplasmic Reticulum Protein 1) is a protein coding gene located on human chromosome 19p13.3. JSRP1 is also known as JP45 and JP-45. The human JSRP1 gene encodes a 36319 Da protein containing 331 amino acids. The JSRP1 protein is biasedly expressed in prostate, stomach and other tissues. JSRP1 is associated with some diseases, including Atrophic Muscular Disease and Myopathy, Tubular Aggregate, 1.

JSRP1 Antibody (1)

    JSRP1 cDNA Clone (1)


    In expression vector

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    JSRP1 Background

    The sarcoplasmic reticulum (SR) is an intracellular membrane compartment that controls intracellular calcium concentration and therefore plays a role in excitation-contraction coupling. JP-45 (also JP45; encoded by JSRP1) is an integral protein constituent of the skeletal muscle sarcoplasmic reticulum junctional face membrane interacting with Ca(v) 1.1 (the α.1 subunit of the voltage-sensing dihydropyridine receptor, DHPR) and the luminal calcium-binding protein calsequestrin. Mouse and human JP45 share 50% amino acid identity overall and 91% identity within the transmembrane domain. Two JSRP1 variants have been found in the human population: c.323C>T (p.P108L) in exon 5 and c.449G>C (p.G150A) in exon 6.

    JSRP1 References

    • Yasuda T, et al. (2013) Jp-45/jsrp1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor. Hum Mutat 34 (1): 184-190.

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