JMJD6 Antibodies, cDNA Clones Research Reagents

JMJD6 (Jumonji Domain Containing 6, Arginine Demethylase And Lysine Hydroxylase, also known as PSR; PTDSR; PTDSR1), located on 17q25.1, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. The gene produces a 46462 Da protein composed of 403 amino acids. This gene encodes a nuclear protein with a JmjC domain. Diseases such as Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency and Pancreatitis are associated with JMJD6. The related pathways of JMJD6 include Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

JMJD6 Antibody (1)

    JMJD6 cDNA Clone (15)

    JMJD6 qPCR Primer (1)

    JMJD6 Background

    JMJD6 (Jumonji Domain Containing 6, Arginine Demethylase And Lysine Hydroxylase) is a Protein Coding gene. This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. JMJD6 is a member of the Jumonji C family of Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases. It possesses unique bi-functional oxygenase activities, acting as both an arginine demethylase and a lysyl-hydroxylase. JMJD6 has been reported to be over-expressed in oral, breast, lung, and colon cancers and plays important roles in the regulation of transcription through interactions with transcription regulator BRD4, histones, U2AF65, Luc7L3, and SRSF11. Diseases associated with JMJD6 include Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency and Pancreatitis.

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