JADE1/PHF17 Antibodies, cDNA Clones Research Reagents

JADE1 (Jade Family PHD Finger 1, also known as PHF17), located on 4q28.2, is a Protein Coding gene. The encoded protein belongs to the JADE family. The full-length JADE1 polypeptide bears one canonical and one extended PHD zinc finger domain. Other domains include the N-terminal candidate PEST domain, Enhancer of the polycomb-like domain, and the C-terminal nuclear localization (NLS) signal. JADE1 is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity. It may also act as a renal tumor suppressor and negatively regulates canonical Wnt signaling.

JADE1/PHF17 Antibody (1)

    JADE1/PHF17 cDNA Clone (1)

    NM_001287437.1

    In expression vector

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    JADE1/PHF17 Background

    The family of JADE proteins includes three paralogues encoded by individual genes and designated PHF17 (JADE1), PHF16 (JADE2), and PHF15 (JADE3). All three JADE proteins bear in tandem two Plant Homeo-domains (PHDs) which are zinc finger domains. Two isoforms of JADE1, JADE1S, and JADE1L, bind HBO1 and promote acetylation of histones in a chromatin context. The N-terminal region of JADE1 functions as a platform that brings together the catalytic HBO1 subunit with its cognate H3-H4 substrate for histone acetylation. Renal cancer is the major cause of mortality due to abnormal functioning of von Hippel-Lindau (pVHL) and Jade Family PHD Finger 1 (JADE1) complex. E3 ubiquitin ligase JADE1 is stabilized by pVHL interaction through its plant homeodomains (PHDs). JADE1 acts as a renal tumor suppressor that promotes the ubiquitination and degradation of β-catenin by inhibiting canonical WNT signaling.

    JADE1/PHF17 References

    • Siriwardana NS, et al. (2015) The novel function of jade1s in cytokinesis of epithelial cells. Cell Cycle 14 (17): 2821-2834.
    • Shafique S, et al. (2019) Structural basis for renal cancer by the dynamics of pvhl-dependent jade1 stabilization and β-catenin regulation. Prog Biophys Mol Biol 145 65-77.
    • Panchenko MV (2016) Structure, function and regulation of jade family phd finger 1 (jade1). Gene 589 (1): 1-11.
    • Han J, et al. (2018) The scaffolding protein jade1 physically links the acetyltransferase subunit hbo1 with its histone h3-h4 substrate. J Biol Chem 293 (12): 4498-4509.

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