ILT4 Proteins, Antibodies, cDNA Clones Research Reagents

LILRB2 (Leukocyte Immunoglobulin Like Receptor B2, also known as ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10), located on 19q13.42, is a Protein Coding gene. The gene produces a 65039 Da protein composed of 598 amino acids. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. Diseases such as Hymenolepiasis are associated with LILRB2. The related pathways of LILRB2 include Innate Immune System and Class I MHC mediated antigen processing and presentation.

ILT4 Protein (3)

    ILT4 Antibody (5)

      ILT4 cDNA Clone (13)

      BC036827

      ILT4 qPCR Primer (1)

      ILT4 Lysate (2)

        ILT4 Background

        ILT4, also known as LILRB2, is a member of the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for the ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

        ILT4 References

        • Colonna M., et al.,(1997), A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186:1809-1818.
        • Borges L., et al., (1997), A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.J. Immunol. 159:5192-5196.
        • Grimwood J., et al.,(2004), The DNA sequence and biology of human chromosome 19.Nature 428:529-535.

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