ILT4 Proteins, Antibodies, cDNA Clones Research Reagents

LILRB2 (Leukocyte Immunoglobulin Like Receptor B2, also known as ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10), located on 19q13.42, is a Protein Coding gene. The gene produces a 65039 Da protein composed of 598 amino acids. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. Diseases such as Hymenolepiasis are associated with LILRB2. The related pathways of LILRB2 include Innate Immune System and Class I MHC mediated antigen processing and presentation.
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All ILT4 Reagents

ILT4 General Information

ILT4 Protein (3)

Species

    ILT4 Antibody (5)

    Application:
    Clonality:
    Host:

      ILT4 cDNA Clone (13)

      BC036827

      In cloning vector

      In cloning vector

      In expression vector

      untagged

      C-GFPSpark C-OFPSpark C-DDK tag N-DDK tag C-His tag N-His tag C-HA tag N-HA tag C-Myc N-Myc

      In lentiviral vector

      C-GFPSpark

      ILT4 qPCR Primer (1)

      ILT4 Lysate (2)

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        ILT4 Background

        ILT4, also known as LILRB2, is a member of the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for the ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

        ILT4 References

        • Colonna M., et al.,(1997), A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186:1809-1818.
        • Borges L., et al., (1997), A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.J. Immunol. 159:5192-5196.
        • Grimwood J., et al.,(2004), The DNA sequence and biology of human chromosome 19.Nature 428:529-535.

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