ILKAP Proteins, Antibodies, cDNA Clones Research Reagents

All ILKAP reagents are produced in house and quality controlled, including 2 ILKAP Antibody, 16 ILKAP Gene, 2 ILKAP IP Kit, 1 ILKAP Lysate, 1 ILKAP Protein, 1 ILKAP qPCR. All ILKAP reagents are ready to use.

ILKAP Protein (1)

    ILKAP Antibody (2)

      ILKAP cDNA Clone (16)


      In expression vector

      ILKAP qPCR Primer (1)

      ILKAP Lysate (1)

        ILKAP Background

        Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is cytoplasm protein which belongs to thePP2C family. ILKAP contains onePP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. ILKAP may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. ILKAP selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. ILKAP inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Integrin-linked kinase ( ILK ) plays key roles in a variety of cell functions, including cell proliferation, adhesion and migration. Within the cell, ILK localizes to multiple sites, including the cytoplasm, focal adhesion complexes that mediate cell adhesion to extracellular substrates, as well as cell-cell junctions in epidermal keratinocytes. Nuclear ILK can be rapidly exported into the cytoplasm through a CRM1-dependent pathway, and its export is enhanced by the type 2C protein phosphatase ILKAP. Nuclear localization of ILK in epidermal keratinocytes is associated with increased DNA synthesis, which is sensitive to inhibition by ILKAP.

        ILKAP References

        • Leung-Hagesteijn C. et al., 2001, EMBO J. 20: 2160-70.
        • Kumar,A.S. et al., 2004, Oncogene. 23 (19):3454-61.
        • Lammers,T. et al., 2007, Crit Rev Biochem Mol Biol. 42 (6):437-61.
        • Nakrieko,K.A. et al., 2008, Cell Cycle. 7 (14):2157-66.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.