ILKAP Proteins, Antibodies, cDNA Clones Research Reagents

ILKAP (ILK Associated Serine/Threonine Phosphatase, also known as PP2CD; PPM1O; ILKAP2; ILKAP3; PP2C-DELTA), located on 2q37.3, is a Protein Coding gene. The gene produces a 42907 Da protein composed of 392 amino acids. ILKAP is a nuclear protein that belongs to the protein phosphatase-2C (PP2C) family. The ILKAP protein contains a catalytic domain that shares approximately 30% identity with the catalytic domains of mammalian PP2C proteins. It plays roles in signal transduction, cell survival, and apoptosis through dephosphorylation of serine/threonine residues. The related pathways of ILKAP include AKT Signaling Pathway.

ILKAP Protein (1)

    ILKAP Antibody (2)

      ILKAP cDNA Clone (16)

      NM_030768.2

      In expression vector

      ILKAP qPCR Primer (1)

      ILKAP Lysate (1)

        ILKAP Background

        Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest levels expressed in striated muscle. Much lower levels are evident in various smooth muscle tissues. ILKAP may play a role in the regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. ILKAP selectively associates with integrin-linked kinase (ILK), to modulate cell adhesion and growth factor signaling. ILKAP inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Integrin-linked kinase ( ILK ) plays key roles in a variety of cell functions, including cell proliferation, adhesion, and migration. Within the cell, ILK localizes to multiple sites, including the cytoplasm, focal adhesion complexes that mediate cell adhesion to extracellular substrates, as well as cell-cell junctions in epidermal keratinocytes. Nuclear ILK can be rapidly exported into the cytoplasm through a CRM1-dependent pathway, and its export is enhanced by the type 2C protein phosphatase ILKAP. Nuclear localization of ILK in epidermal keratinocytes is associated with increased DNA synthesis, which is sensitive to inhibition by ILKAP.

        ILKAP References

        • Leung-Hagesteijn C. et al., 2001, EMBO J. 20: 2160-70.
        • Kumar,A.S. et al., 2004, Oncogene. 23 (19):3454-61.
        • Lammers,T. et al., 2007, Crit Rev Biochem Mol Biol. 42 (6):437-61.
        • Nakrieko,K.A. et al., 2008, Cell Cycle. 7 (14):2157-66.

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