IL20RB Proteins, Antibodies, cDNA Clones Research Reagents

IL20RB (Interleukin 20 Receptor Subunit Beta, also known as DIRS1; FNDC6; IL-20R2), located on 3q22.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 35076 Da protein composed of 311 amino acids. IL20RB and IL20RA form a heterodimeric receptor for interleukin-20 (IL20). Human IL24 interacts with both IL20RA/IL20RB and IL22RA/IL20RB heterodimers. The related pathways of IL20RB include AKT Signaling Pathway and PEDF Induced Signaling.

IL20RB Protein (6)

    IL20RB Antibody (5)

      IL20RB cDNA Clone (50)


      IL20RB Lysate (6)

        IL20RB Background

        IL20RB belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors: cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20, and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family. IL20RB and IL20RA form a heterodimeric receptor for interleukin-20.

        IL20RB References

        • Zhu H, et al. (2009) Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines. Hepatobiliary Pancreat Dis Int. 8(4):402-6.
        • Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.
        • Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5):445-51.

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