IL-18Rβ / IL-18RAcP Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL18RAP (Interleukin 18 Receptor Accessory Protein, also known as ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta), located on 2q12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 68310 Da protein composed of 599 amino acids. The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. Diseases such as Crohn's Disease and Inflammatory Bowel Disease are associated with IL18RAP. The related pathways of IL18RAP include the Immune response IL-23 signaling pathway and PEDF Induced Signaling.

IL-18Rβ / IL-18RAcP Protein (5)

    IL-18Rβ / IL-18RAcP Antibody (9)

      IL-18Rβ / IL-18RAcP ELISA Kit & Match Antibody ELISA Pair Set (1)

      IL-18Rβ / IL-18RAcP cDNA Clone (39)

      NM_003853.2
      NM_010553.2
      XM_001108108.2

      IL-18Rβ / IL-18RAcP Lysate (5)

        IL-18Rβ / IL-18RAcP Background

        Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand-binding subunit of the IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high-affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the etiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity, and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.

        IL-18Rβ / IL-18RAcP References

        • Zhernakova A, et al.. (2008) Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet. 82(5): 1202-10.
        • Grisoni ML, et al.. (2009) Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 10: 44.
        • Koskinen LL, et al.. (2009) Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet. 18(6): 1148-55.

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