IL12B Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL12B (Interleukin 12B, also known as CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B), located on 5q33.3, is a Protein Coding gene. The gene produces a 37169 Da protein composed of 328 amino acids. IL12B is a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The IL12 p40 subunit, or IL12B, heterodimerizes with the IL12 p35 subunit (IL12A) to form IL12 and with the IL23 p19 subunit (IL23A) to form IL23. Diseases such as Immunodeficiency 29 and Takayasu Arteritis are associated with IL12B.

IL12B Protein (9)

IL12B Antibody (15)

    IL12B ELISA Kit & Match Antibody ELISA Pair Set (1)

    IL12B cDNA Clone (91)


    IL12B Lysate (9)

      IL12B Background

      Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor-like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine is important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine that functions in innate and adaptive immunity.

      IL12B References

      • Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
      • Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
      • Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.