IL1-F8 Proteins, Antibodies, cDNA Clones Research Reagents

IL36B (Interleukin 36 Beta, also known as FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)), located on 2q14.1, is conserved in Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 18522 Da protein composed of 164 amino acids. The protein encoded by this gene is a member of the interleukin 1 cytokine family. Diseases such as Pulmonary Hemosiderosis and Periostitis are associated with IL36B. The related pathways of IL36B include PEDF Induced Signaling and the Innate Immune System.

IL1-F8 Protein (3)

    IL1-F8 Antibody (7)

      IL1-F8 cDNA Clone (26)

      NM_173178.1
      NM_027163.4

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      IL1-F8 Background

      Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includes four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.

      IL1-F8 References

      • Magne D, et al. (2006) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Arthritis Research & Therapy. 8: R80.
      • Smith DE, et al. (2000) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. The Journal of Biological Chemistry. 275: 1169-75.

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