IL-7 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL7 (Interleukin 7, also known as IL-7), located on 8q21.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 20187 Da protein composed of 177 amino acids. The protein encoded by this gene is a cytokine important for B and T cell development. IL7 belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. Diseases such as Epidermodysplasia verruciformis 5 and Epidermodysplasia Verruciformis 1 are associated with IL7. The related pathways of IL7 include PEDF Induced Signaling and IL-7 Signaling Pathway.

IL-7 Protein (4)

    IL-7 Antibody (6)

      IL-7 ELISA Kit & Match Antibody ELISA Pair Set (2)

      IL-7 cDNA Clone (52)


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      IL-7 Background

      IL7, also known as interleukin 7, is a hematopoietic growth factor that belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells and may serve as a regulatory factor for intestinal mucosal lymphocytes.

      IL-7 References

      • Watanabe M, et al. (1995) Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.
      • J Clin Invest. 95(6):2945-53. Sawa Y, et al. (2009) Hepatic interleukin-7 expression regulates T cell responses. Immunity. 30 (3):447-57.
      • Flad HD, et al. (1996) Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol. 26(10): 2541-4.

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