IL-29 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IFNL1 (Interferon Lambda 1, also known as IL29; IL-29), located on 19q13.2, is a Protein Coding gene. The gene produces a 21898 Da protein composed of 200 amino acids. IFNL1 has significant antiviral activity and immunoregulatory properties and appears to inhibit T helper-2 (Th2) responses. It has a conserved cysteine pattern and amphipathic profile similar to other helical cytokine family members. Diseases such as Psoriasis 12 and Viral Infectious Disease are associated with IFNL1. The related pathways of IFNL1 include all-trans-retinoic Acid Mediated Apoptosis and JAK-STAT signaling pathway.

IL-29 Protein (2)

    IL-29 Antibody (7)

      IL-29 ELISA Kit & Match Antibody ELISA Pair Set (2)

      IL-29 cDNA Clone (8)

      NM_172140.1

      In lentiviral vector

      IL-29 qPCR Primer (1)

      IL-29 Lysate (2)

        IL-29 Background

        Interleukin-29 (IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein that belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by a viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

        IL-29 References

        • Li MC, et al. (2006) Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. Acta Pharmacol Sin. 27(4): 453-9.
        • Wang J, et al. (2009) Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. J Immunol. 182(3): 1296-304.
        • Jordan WJ, et al. (2007) Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29). Genes Immun. 8(1): 13-20.

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