IL-27 Proteins, Antibodies, cDNA Clones Research Reagents

IL27 (Interleukin 27, also known as p28; IL30; IL-27; IL27A; IL-27A; IL27p28), located on 16p12.1-p11.2, is conserved in chimpanzee, dog, cow, mouse, and rat. The gene produces a 27493 Da protein composed of 243 amino acids. The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. Diseases such as Visceral Leishmaniasis and Posterior Uveitis are associated with IL27. The related pathways of IL27 include PEDF Induced Signaling and IL27-mediated signaling events.

IL-27 Protein (3)

    IL-27 Antibody (7)

      IL-27 cDNA Clone (39)

      NM_145659.3
      NM_145636.1
      XM_344962.4

      IL-27 qPCR Primer (2)

      IL-27 Lysate (2)

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        IL-27 Background

        IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a heterodimeric cytokine complex, and associates with another subunit EBI3 (EBV-induced gene 3), and IL-12 p40-related protein (IL-27B). IL-27 protein is an early product of activated antigen-presenting cells and drives the rapid clonal expansion of naive CD4(+) T cells and plays a role in the early regulation of Th1 cells initiation which drives efficient adaptive immune response. IL-27 protein has an antiproliferative activity on melanomas through WSX-1/STAT1 signaling. Thus, IL-27 protein may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy.

        IL-27 References

        • Hisada M, et al. (2004) Potent antitumor activity of interleukin-27. Cancer Res. 64(3): 1152-6.
        • Larousserie F, et al. (2005) Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells. Am J Pathol. 166(4): 1217-28.
        • Seita J, et al. (2008) Interleukin-27 directly induces differentiation in hematopoietic stem cells. Blood. 111(4): 1903-12.

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