IGFBP4 Proteins, Antibodies, cDNA Clones Research Reagents

IGFBP4 (Insulin-Like Growth Factor Binding Protein 4, also known as BP-4; IBP4; IGFBP-4; HT29-IGFBP), located on 17q21.2, is a Protein Coding gene. The gene produces a 27934 Da protein composed of 258 amino acids. Human IGFBP4 encodes a polypeptide, which includes a 21-amino acid signal sequence. The protein is very hydrophilic, which may facilitate its ability as a carrier protein for the IGFs in the blood. Diseases such as Renal Osteodystrophy and Insulin-Like Growth Factor I are associated with IGFBP4. The related pathways of IGFBP4 include Myometrial Relaxation and Contraction Pathways and Metabolism of proteins.

IGFBP4 Protein (3)

    IGFBP4 Antibody (5)

      IGFBP4 cDNA Clone (39)


      IGFBP4 Lysate (3)

        IGFBP4 Background

        Insulin-like growth factor-binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in the liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity.

        IGFBP4 References

        • Wang J, et al. (1998) Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139(5): 2605-14.
        • Chernausek SD, et al. (1995) Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4. J Biol Chem. 1995 May 12;270(19):11377-82.

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