IGFBP4 Proteins, Antibodies, cDNA Clones Research Reagents

IGFBP4 (Insulin-Like Growth Factor Binding Protein 4, also known as BP-4; IBP4; IGFBP-4; HT29-IGFBP), located on 17q21.2, is a Protein Coding gene. The gene produces a 27934 Da protein composed of 258 amino acids. Human IGFBP4 encodes a polypeptide, which includes a 21-amino acid signal sequence. The protein is very hydrophilic, which may facilitate its ability as a carrier protein for the IGFs in the blood. Diseases such as Renal Osteodystrophy and Insulin-Like Growth Factor I are associated with IGFBP4. The related pathways of IGFBP4 include Myometrial Relaxation and Contraction Pathways and Metabolism of proteins.

IGFBP4 Protein (3)

    IGFBP4 Antibody (5)

      IGFBP4 cDNA Clone (39)

      NM_001552.2
      NM_010517.3
      XM_001097914.2

      IGFBP4 Lysate (3)

        IGFBP4 Background

        Insulin-like growth factor-binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in the liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity.

        IGFBP4 References

        • Wang J, et al. (1998) Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139(5): 2605-14.
        • Chernausek SD, et al. (1995) Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4. J Biol Chem. 1995 May 12;270(19):11377-82.

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