IGFBP2 Proteins, Antibodies, cDNA Clones Research Reagents

IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, also known as IBP2; IGF-BP53), located on 2q35, is a Protein Coding gene. The gene produces a 34814 Da protein composed of 325 amino acids. IGFBP2 is an insulin-like growth factor-binding protein (IGFBP). IGFBP2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to the potential involvement of IGFBP2 in tumorigenesis. Diseases such as Malignant Ovarian Cyst and Insulin-Like Growth Factor I are associated with IGFBP2.

IGFBP2 Protein (3)

    IGFBP2 Antibody (8)

      IGFBP2 cDNA Clone (30)

      NM_000597.2

      In expression vector

      NM_008342.3
      NM_013122.2

      In cloning vector

      In lentiviral vector

      XM_001087071.2

      IGFBP2 Lysate (3)

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        IGFBP2 Background

        IGFBP-2, also known as IGFBP2, is an insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs, control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to the potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates.

        IGFBP2 References

        • Han VK, et al. (1996) The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface. J Clin Endocrinol Metab. 81(7): 2680-93.
        • Binkert C, et al. (1989) Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2) . EMBO J. 8(9):2497-502.
        • Wolf E, et al. (2000) Effects of IGFBP-2 overexpression in vitro and in vivo. Pediatr Nephrol. 14 (7):572-8.

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