IGF-II Proteins, Antibodies, cDNA Clones Research Reagents

IGF2 (Insulin-Like Growth Factor 2, also known as GRDF; SRS3; IGF-II; PP9974; C11orf43), located on 11p15.5, is a Protein Coding gene. The gene produces a 20140 Da protein composed of 180 amino acids. IGF2 is a protein hormone involved in the regulation of cell proliferation, growth, migration, differentiation, and survival. The prepro-IGF2 protein contains an N-terminal signal sequence followed by the mature peptide and a C-terminal extension called the E domain. Both the N-terminal signal sequence and E domains are proteolytically removed to generate the mature 67-amino acid peptide.

IGF-II Protein (1)

    IGF-II Antibody (6)

      IGF-II cDNA Clone (41)


      In expression vector

      In lentiviral vector


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      IGF-II Background

      Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. IGF-2 and exhibited statistically significant, positive associations with colorectal cancer risk when cases were confined to those diagnosed within a relatively short period after enrolment. Circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer. IGF-2/IGF-II appears to be involved in the progression of many tumors. It binds to at least two different types of receptors: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumor suppressor function—it mediates IGF 2 degradation. Mutation of M6-P/IGF 2R causes both diminished growth suppression and augmented growth stimulation. This study aimed to investigate the role of IGF 2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer.

      IGF-II References

      • Harvey MB, et al. (1991) IGF-2 receptors are first expressed at the 2-cell stage of mouse development. Development. 111(4): 1057-60.
      • Peters G, et al. (2003) IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 443(2): 139-45.
      • Burrow S, et al. (1998) Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. J Surg Oncol. 69(1): 21-7.

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